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KMID : 1025720160350020046
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Journal of Dental Implant Research
2016 Volume.35 No. 2 p.46 ~ p.52
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A clinical & radiologic study of bone remodeling effects using rhBMP-2 for maxillary sinus graft
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Kim Jung-Ho
Kim Uk-Cheon
Lee Jang-Yeol
Kim Hyun-Chull
Kim Soo-Nam
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Abstract
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Purpose: The aim of this study is to evaluate effects using rhBMP-2 for maxillary sinus graft, especially focused on loading time and stability of postoperative period.
Materials and Methods: 73 partially or completely edentulous patients who have been treated in Livingwell dental hospital between 2011 to 2015 with atrophic maxillary posterior were selected. Crestal and lateral approach were used for sinus floor elevation procedure. A total of 116 implants-Tapered Screw Vent implant (Zimmer, USA), TS3 (Osstem, Korea), CMI IS-II active (Neobiotech, Korea)-were placed in grafted maxillary sinus. The rhBMP-2 (Cowell BMP; Cowellmedi inc. Korea, Novosis; Daewoong co. Inc. Korea) mix to demineralized dentin matrix (DDM), allograft (CG-Oss, CGBio, Korea) or ??TCP (CERASORBⓡ, Curasan, Germeny) was grafted into sinus mainly. We spin the RFA values as the basis for determining the loading time. If the ISQ value at day to load were ＜65, we wait, and the ISQ values was measured again 1 weeks later until the required level is reached. Panoramic radiographs or CBCT were taken preoperatively, postoperatively (1 day after operation, T0), and then at yearly intervals (1 year after surgery: T1, 2 year after surgery: T2, 3 years after
surgery: T3) for evaluate the peri-implant bone and maxillary sinuses.
Results: 5 implants failed due to infection and 2 implants lost to follow up. The average preoperatively height of the maxillary alveolar bone was 5.17±3.28 mm, and minimum was 0.1 mm. The Mean period to load implants was 142.33±40.48 days, and minimum was 56 days. The average HGB was 2.12±0.94 mm at T1, 1.53±0.61 mm at T2, 1.22±0.72 mm at T3. The average resorption rate of HGB was 28.33±14.59% at T1, 37.28±16.99% at T2, 37.75±17.02% at T3. Statistical analysis was performed with postoperative data of T1 period. There are no significant difference of resorption rate (p-value=0.83) between early loading group (27.87±13.86%) and conventional loading group (28.82±15.67%).
Conclusions: The result indicated that using rhBMP-2 for maxillary sinus graft could shorten the loading time stably.
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KEYWORD
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Sinus graft, rhBMP-2, DDM
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